The Neapolitan Mastiff is a giant and powerful dog breed known for its massive size, distinctive wrinkles, and protective nature. These dogs typically weigh between 110 to 155 pounds and stand around 24 to 31 inches tall at the shoulder. Neapolitan Mastiffs have a massive and heavily wrinkled build, with loose skin that forms folds and wrinkles across their body. They have a solemn and watchful expression, with deep-set eyes and drooping, pendant ears.